Recent Scientific Papers

Publications by Professor Jayantha Arnold

Original articles:

  1. Hendry BM, Stafford N, Arnold AD, Sangwaiya A, Manglam V, Rosen SD, Arnold J. Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID-19 patients. Pharmacol Res Perspect. 2020 Aug;8(4):e00631.

 

  1. Sangwaiya A, Manglam V, Busbridge M, Thursz M, Arnold JD. Blunted increase in serum hepcidin as response to oral iron in HFE-hemochromatosis. Eur J Gastroenterol Hepatol 2011;23(8):721-4.

 

  1. Walker DG, Williams HR, Kane SP, Mawdsley JE, Arnold JD, McNeil I, Thomas HJ, Teare JP, Hart AL, Pitcher MC, Walters JR, Marshall SE, Orchard TR. Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK. Am J Gastroenterol 2011;106(7):1281-9.

 

  1. Soon E, Treacy CM, Toshner MR, MacKenzie-Ross R, Manglam V, Busbridge M, Sinclair-McGarvie M, Arnold JD, Sheares KK, Morrell NW, Pepke-Zaba J. Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension. Thorax 2011;66(4):326-32.

 

  1. Arnold JD, Sangwaiya A, Manglam V, Thursz M, Beaumont C, Kannengiesser C, Busbridge M. Hepcidin levels in hereditary hyperferritinemia: Insights into the iron-sensing mechanism in hepatocytes. World J Gastroenterolgy 2010; 6(28):3541-5.

 

  1. Arnold JD, Sangwaiya A, Manglam V, Geoghegan F, Thursz M, Busbridge M. Presence of hepcidin-25 in biological fluids: bile, ascitic and pleural fluids. World J Gastroenterol 2010;16(17):2129-33.

 

  1. Busbridge M, Griffiths C, Ashby D, Gale D, Arnold J, Sangwaiya A, Chapman RS. Development of a novel immunoassay for the iron regulatory peptide hepcidin. Br J Biomed Sci 2009;66(3):150-7.

 

  1. Arnold JD, Sangwaiya A, Bhatkal B, Geogeghan F, Busbridge M. Hepcidin and inflammatory bowel disease : dual role in host defence and iron homeostasis. European Journal of Gastroenterology and Hepatology 2009;21(4): 425-429.

 

  1. Arnold JD, Sangwaiya A, Bhatkal B, Arnold A. Defective release of Hepcidin not defective synthesis is the primary pathogenic mechanism in HFE-Haemochromatosis. Medical Hypotheses 2008;70(6): 1197-1200.

 

  1. Karvounis E, Griniatsos J, Arnold JD, Atkin G, Martinez-Isla A. Why does Laparoscopic common Bile Duct Exploration Fail? International Surgery 2006; 91: 90-93.

 

  1. Mumford AD, Cree IA, Arnold JD, Hagan MC, Rixon KC,

    Harding J. The lens in hereditary hyperferritinaemia cataract   

   syndrome contains crystalline deposits of L ferritin. British   

   Journal of Opthalmology 2000; 84: 697-700

 

  1. Arnold JD, Mumford AD, Lindsay JO, Hegde U, Hagan M,

Hawkins JR. Hyperferritinaemia in the absence of iron overload. Gut 1997; 41:408-410

 

  1. Seery JP, Henshaw DW, Sandhu PJ, Mather HM, Ahmad F,

McNeil I, Arnold JD. Helicobacter pylori infection and upper gastrointestinal pathology in a British immigrant Indian community. Eur J Gastroenterol Hepatol 1997;9 (6): 647-648

 

  1. Swift GL, Arnold JD, Williams GT, Williams BD, Rhodes J, Khan F.Risk of ulceration with long term indomethacin: endoscopic and histological changes in upper gastro-intestinal mucosa. Digestion 1992;53 (1-2): 88-93.

 

  1. Swift GL, Arnold JD, Williams GT, Williams BD, Rhodes J, Khan F.

A comparison of upper gastrointestinal mucosal damage by standard and delayed release indomethacin. Alimentary Pharmacology and Therapeutics 1992;6:717-725.

 

  1. Arnold JD, Friedman E, Ambepitiya G, Woodroffe FJ.

Rapid glucose decline and relative hypoglycaemia: electroencephalographic monitoring for neuroglycopenia in man. European Journal of Internal Medicine 1992;2,223-228

 

  1. Arnold JD, Courtenay-Evans RJ, Whitfield R, O’Reilly JF,Petrie GR , Higgins AJ, Swift CG. Comparative assessment of enprofylline and theophylline for chronic obstructive airways disease in the elderly. Med. 1990;84(3):211- 5.

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Case reports:

  1. Cheent K, Nolan J, Shariq S, Kiho L, Pal A, Arnold JD. Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn’s disease. J Crohns Colitis 2010;4(5):603-5. (cited 260 times as per Google scholar)

 

  1. Sangwaiya A, Patel A, Chan J, Arnold JD.  Simple Liver Cyst as a Focus of Salmonella paratyphi Abcess: A Case Report. J Tropical Medicine 2009; doi:10.1155/2009/456810.

 

  1. Paskaran P, Murugananthan AU, Manglam V, Arnold J, Pal A. A case report of hepatitis e infection leading to acute liver failure and transplantation. Clin Med Case Rep. 2008;1:133-135.

 

  1. Dubb S, Arnold A, Banavali S, Arnold JD. Acute Appendagitis Presenting with Features of Appendicitis: Value of Abdominal CT Evaluation. Case reports in Gastroenterology 2008;2:191-195.

 

  1. Ngatchu T, Sangwaiya A, Dabiri A, Dhar A, McNeil I, Arnold   Alcoholic ketoacidosis with multiple complications: a Case Report. Emergency Medical Journal 2007;24(11):776-777.

 

  1. Beales IL, Jackson JE, Rudolf M, Arnold JD. Successful use of a transjugular intrahepatic portosystemic stent shunt to control severe refractory oesophageal variceal haemorrhage in a poor risk patient. Postgrad Med J 1993; 69: 945-947.

 

  1. Arnold JD, Mitchell ABS. Conn’s Syndrome from an ectopic adrenal tumour. Postgrad Med J 1989;65:847-848.

Abstracts:

  1. Sangwaiya A, Arnold JD, Busbridge M, Manglam V, Thursz M. Immunohistochemical staining of human liver and duodenal tissue for detection of hepcidin. Gut 2009:58 (Suppl 2)A488.

 

  1. Sangwaiya A, Arnold JD, Manglam V, Busbridge M, Thursz M. Serum hepcidin levels in alcoholic liver disease. Gut 2009:58 ( Suppl 2)A356.

 

  1. Manglam V, Sangwaiya A, Pal A, Busbridge M, Arnold JD. Hepcidin in ascitic fluid: an antimicrobial peptide. Gut 2009:58 (Suppl 2)A356.

 

  1. Woghiren OR, Howard A, Arnold JD, Ghosh S, Walters JRF. Colonic mucosal cytokine expression differs in newly diagnosed and chronic inflammatory bowel diseases. Gut 2009:58 ( Suppl 2) A159.

 

  1. Sangwaiya A, Arnold JD, Manglam V, Thursz M, Geoghegan F, Busbridge M. Highly sensitive assay to detect hepcidin in biological fluids: presence of hepcidin in pleural fluid. Thorax 2009;64 (Suppl 1V): A80.

 

  1. Arnold JD, Sangwaiya A, Busbridge M, Bhatkal B, Geogeghan F. Serum hepcidin levels in inflammatory bowel disease compared with healthy controls. Gut 2008:57: A340.

 

  1. Walker DG, Williams HRT, Arnold JD, Kane S, Thomas HJW, Teare JP, Jewell DP, Orchard TR. The clinical phenotype of inflammatory bowel disease in the UK South Asian population. Gut 2008:57: A134.

 

  1. Walker DG, Williams HRT, Arnold JD, Kane S, Thomas HJW, Teare JP, Cox IJ, Orchard TR. A comparison of the urinary metabolic profile of Caucasians and UK South Asians with inflammatory bowel disease. Gut 2008:57:A343.

 

  1. Arnold JD, Sangwaiya A, Busbridge M, Bhatkal B. Serum hepcidin and prohepcidin levels in Hereditary Hyperferritinaemia Cataract Syndrome: insight into iron sensor in hepatocytes. Gut 2008:57:A286.

 

  1. Arnold JD, Sharif A, Sangwaiya A, Busbridge M, Bhatkal B, Thursz M. Evidence of hepcidin secretion in bile: insights into pathogenesis of Hereditary Haemochromatosis. Gut 2008:57:A53.

 

  1. Busbridge M, Griffths C, Chapman RS, Arnold J, Sangwaiya A. Relationship between Hepcidin and Pro-hepcidin with Ferritin from biochemical analyses on human samples. Clinical Chemistry 2008;54: Suppl A39.

 

  1. Arnold JD, Sangwaiya A, Sivagnanaratnam A, McNeil NI, Holloway P. Value of serum transferrin receptor levels in assessing iron status in patients with Inflammatory Bowel Disease. Gut 2005;54:A91.

 

  1. Arnold JD, Sivagnanaratnam A, Sangwaiya F, Ahmad P, Holloway P, McNeil NI. Prevalence of Helicobacter pylori infection in white Caucasian and South Asian patients with Inflammatory Bowel Disease. Gut 2005;54: A90-A91.

 

  1. Mumford AD, Cree IA, Arnold JD, Hagan MC, Rixon KC,

          Harding J. The lens in hereditary hyperferritinaemia cataract

          syndrome contains crystalline L-Ferritin deposits. British

          Journal of Haematology 1999;suppl: p 63.

 

  1. Lindsay JO, Mumford AD, Hagan M, Hegde U, Hawkins JR,

Arnold JD. Hyperferritinaemia with cataracts: A new hereditary condition. Gut 1996;suppl A10, p39.

 

  1. Arnold JD, Faizal A, Pathy J, Morris J, Lawrie BW. Impacted stones in the common bile duct and painless jaundice. Abstracts of the World Congresses of gastroenterology. Sydney 1990. Abingdon: The Medicine Group 1990:A806

 

  1. Arnold JD, Williams GT, Khan FN, Wilkins WE, Morris JS, Rhodes J. Effect of non steroidal anti inflammatory drugs on human jejunal morphology. Gut 1990;31: 1194.

 

  1. Arnold JD, Forgacs IC, Ford TA, Hutchison DCS, Swift CG.

Effect of the antagonist flumazenil on diazepam induced respiratory depression during endoscopy. Clinical Science 1990;78:3.

 

  1. Swift GL, Arnold JD, Rhodes J. Oesophagitis associated with chronic NSAID use – an under recognised problem. Post Grad Med J 1991;67:485-486.

 

  1. Arnold JD,Williams GT, Swift G, Morris JS, Rhodes J.

Gastric metaplasia in the distal duodenum and chronic NSAID usage. Post Grad Med J 1991;67:695.

 

  1. Arnold JD, Swift GL, Williams GT, Wilkins WE, Morris J,

Rhodes J. Large intestinal inflammation associated with oral non steroidal anti inflammatory drugs. Gut 1991;32: 1214.

 

  1. Arnold JD, Leslie RDG, Heller A, Swift CG. Extra pancreatic actions of sulphonylureas: absence of effect on hepatic insulin extraction. Postgrad Med J 1990;66:579.

 

  1. Arnold JD, Friedman E, Woodroffe FJ. Does rapid fall in blood glucose produce relative neuroglycopenia and trigger counter regulatory hormonal response? Diabetic Medicine 1988;5:A29.

 

  1. Lovato S, Arnold J. Which haematological conditions can third year medical students recognise interpreting full blood count results? HAEMATOLOGICAMeeting Abstract: E1467 Volume: 102  Pages: 599-599  Supplement: 2  Published: 26 June 2017  

 

  1. Walker DG, Williams HRT, Padaruth S, Milestone AN, Arnold J, Kane S, Thomas HJW, Teare JP, Hart A, Jewell DP, Orchard TR. Inflammatory bowel disease in Caucasian and UK South Asian patients: difference in clinical phenotype. GutVolume: 58 Pages: A60-A60 Supplement: 1 Published: April 2009

 

  1. Monahan KJ, McNeil NIAN, Arnold J, Orchard T. The frequency of gastrointestinal haemorrhage in 26. Patients treated for acute coronary syndromes: an observational study. Gut Volume: 59  Pages: A20-A21 Supplement: 1  Published: April 2010

 

  1. Sangwaiya A, Busbridge M, Manglam V, Thursz M, Arnold J Hepcidin is responsive to oral iron challenge in healthy volunteers. Journal of HepatologyVolume: 52  Pages: S378-S379 Supplement: 1  Published: 2010

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Published letters

  1. Arnold JD, Wilkins WE, Lawrie BW. Gallbladder function after endoscopic sphincterotomy. Br Med J 1990;300:1585.

 

  1. Arnold JD, Wilkins WE. Non steroidal anti inflammatory drug induced enteropathy. Gut 1991;32:338.

 

  1. Arnold JD. Duodenal ulcers that are difficult to treat. Br Med J 1989; 298: 388.

 

  1. Arnold JD. Antibiotic prophylaxis for endoscopic sphincterotomy. Gut 1988; 29;874-875

 

  1. Arnold JD. Disturbances of insulin secretion in British Asian and white men. Br Med J. 1988;299;914.

 

  1. Arnold JD. Intranasal glucagon for hypoglycaemia. Lancet 1988;2:216.

Guest lectures

 

1st International conference on metal chelation in biology and medicine  Bath, UK 13th Dec 2009. Topic: Dysfunctional iron regulation in gastrointestinal and liver diseases.

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